EVcomplex Webserver

EVcomplex is a method for predicting inter-protein residue interactons. Two multiple sequence alignments for two protein domains are combined by concatenating sequence pairs, one from each of the domain alignments. Pairing is done by genome coordinates; two sequences in the same genome from nearby locations are most likely to be co-expressed and physically interact. These concatenated pairs are then used as an MSA input into the Evolutionary Couplings method, scoring pairs of residues based on evolutionary co-variation. High scoring ECs are examined to distinguish the inter-ECs (which pair two residues from different domains) from the intra-ECs. The high scoring inter-ECs are likely points of interaction in the interface between the two domains.

This webserver lets you predict EVcouplings between two proteins

Start Prediction